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How should you take this medication?

If you take several doses per day, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals. However, if it is almost time for the next dose , skip the missed dose and continue your regular dosing schedule.

If you take Zyban once a day at bedtime and do not remember to take it until the next morning, skip the missed dose. Do not t ake a double dose to make up for a missed one.

Before Taking This Medicine

Stop taking Zyban and call your doctor immediately if you have difficulty breathing or swallowing; notice swelling in your face, lips, tongue, or throat; develop swollen arms and legs; or break out wi th itchy eruptions. These are warning signs of a potentially severe allergic reaction.

If you have a liver or kidney condition, make sure the doctor is aware of it. Your dosage may need to b e reduced. (If you have severe cirrhosis of the liver, your dosage must be reduced.) Also make certain the doctor knows about any heart condition you may have.

Zyban can interfere with your driving ability. Don't drive or operate dangerous machinery until you are certain of the drug's effect on you.

What Is It

Zyban (byoo-PROE-pee-on ) is used to relieve mental depression and is used as part of a support program to help you stop smoking.

Zyban is sold under different brand names for different uses. If you are already taking medicine for mental depression or to help you stop smoking, discuss this with your health care professional before taking Zyban. It is very important that you receive only o ne prescription for Zyban at a time.

What special precautions should I follow?

Drinking of alcoholic beverages should be limited or avoided, if possible, while taking Zyban. This will help prevent seizures.

This medicine may cause some people to feel a false sense of we ll-being, or to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerou s if you are dizzy or are not alert and clearheaded.

What side effects may occur?

Less common side effects may include:
Abnormal thinking, allergic reaction, bronchitis, changes in taste, difficulty breathing, dry skin, fever, hives, hot flashes, increased appetite or loss of appetite, increased blood pressure, migraine, mouth ulcers, muscle pain, neck pain, nosebleed, ringing in the ears, shakiness, sinus inflammation, sleepiness, throbbing heartbeat

Rare side ef fects may include:
Chest pain, feeling of unhappiness, thirst, swelling of the face

If you are using the oral concentrate form of Zoloft, do not take disulfiram (Antabuse)
If you ar e using the oral concentrate form of Zoloft, do not take disulfiram (Antabuse)

Possible food and drug interactions when taking this medication

When you are taking Zyban, it is especially important that your health care professional know if you are taking any of the following:

- Tricyclic antidepressants (amitriptyline [e.g., Elavil ], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil]) or
-
- Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegi line [e.g., Eldepryl], tranylcypromine [e.g., Parnate])¡X Do not take Zyban while you are taking or within 14 days of taking an MAO inhibitor


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