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Other medical problems
Stop taking Zyban and call your doctor immediately if you have difficulty breathing or swallowing; notice swelling in your face, lips, tongue, or throat; develop swollen arms and legs; or break out wi
th itchy eruptions. These are warning signs of a potentially severe allergic reaction.
If you have a liver or kidney condition, make sure the doctor is aware of it. Your dosage may need to b
e reduced. (If you have severe cirrhosis of the liver, your dosage must be reduced.) Also make certain the doctor knows about any heart condition you may have.
Zyban can interfere with your
driving ability. Don't drive or operate dangerous machinery until you are certain of the drug's effect on you.
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Special warnings about this medication
Drinking of alcoholic beverages should be limited or avoided, if possible, while taking Zyban. This will help prevent seizures.
This medicine may cause some people to feel a false sense of we
ll-being, or to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerou
s if you are dizzy or are not alert and clearheaded.
|
Overdose
- difficulty breathing or swallowing
- dizziness
- fainting
- shakiness
- sweating
- confusion
- blurred vision
- seizure
- seeing things or hearing voices
that do not exist (hallucinating)
- loss of consciousness
- rapid or pounding hearbeat
- blurred vision
- lightheadedness
- confusion
- lack of energy
- upset stoma
ch
- jitteriness
|
|
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Significant Interactions:
When you are taking Zyban, it is especially important that your health care professional know if you are taking any of the following:
- Alcohol or
- Antipsychotics (medicine for mental
illness) or
- Corticosteriods(cortisone-like medicine) or
- Fluoxetine (e.g., Prozac) or
- Lithium (e.g., Lithane) or
- Maprotiline (e.g., Ludiomil) or
- Theophylline (e.g., S
omophyllin-T) or
- Trazodone (e.g., Desyrel) or
- Ritonavir (e.g., Norvir)¡XUsing these medicines with Zyban may increase the risk of seizures
|
How should you take this medication?
If you take several doses per day, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals. However, if it is almost time for the next dose
, skip the missed dose and continue your regular dosing schedule.
If you take Zyban once a day at bedtime and do not remember to take it until the next morning, skip the missed dose. Do not t
ake a double dose to make up for a missed one.
|
What is this medicine
Zyban was introduced in the USA in 1985 and was withdrawn in 1986 because of an unacceptable incidence of seizures. In 1989 it was reintroduced in the USA (maximum dose of 450 mg daily). Zyban was fir
st approved in Canada in 1998 as an SR twice-daily formulation. In one RCT buproprion SR, 150 mg daily and 150 mg BID, were similar and more effective than placebo based on physician rated scores of d
epression at 8 weeks.8 In 2 RCTs Zyban (150-400 mg/day) was similar in effectiveness to sertraline (50-200 mg/day) at 8 weeks, but the incidence of satisfaction with sexual functioning was less with s
ertraline (63%) than buproprion (79%) and placebo (78%). 9, 10
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