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Significant Interactions:
If Zovirax is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zovirax with the fo
llowing:
- Cyclosporine (Sandimmune, Neoral)
- Interferon (Roferon-A)
- Probenecid (Benemid)
- Zidovudine (Retrovir)
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Side Effects of This Medicine
Parenteral:
1. Renal toxicity; precipitation of Zovirax crystals can occur in renal tubules if the maximum solubility of free Zovirax (2.5mg/ml at 37?C in water) is exceeded or if the drug is give
n by bolus injection. Serum creatinine and BUN rise and creatinine clearance decreases.
2. Encephalopathic changes: Approximately 1% of patients receiving IV Zovirax manifested encephalopathic cha
nges characterized by lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures or coma.
3. Other: transient elevation of serum creatinine; rash or hives; diaphoresis; hematur
ia; hypotension; headache and nausea; thrombocytosis.
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How should you take this medication?
Zovirax comes as an ointment for use on the skin and as a tablet, capsule, and liquid to take by mouth. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to
explain any part you do not understand. Take Zovirax exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Use this medication as soon as possible
after symptoms appear.
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Precautions Before Using This Medicine
Dehydration or
Kidney disease¡XDehydration or kidney disease may increase blood levels of Zovirax, increasing the chance of side effects
Nervous system problems¡XZovirax may make these probl
s worse
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Symptoms of overdose may include:
Zovirax is generally safe. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.
Symptoms of Zovirax overdose
may include:
- Agitation, kidney failure, lethargy, coma, seizures
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How should you take this medication?
Your medication should not be shared with others, and the prescribed dose should not be exceeded. You can take Zovirax with or without food.
Zovirax ointment should not be used in or near th
e eyes. To reduce the risk of spreading the infection, use a rubber glove to apply the ointment.
Zovirax cream should not be used in or near the eyes, or inside the nose or mouth. The medica
tion can, however, be applied on the outside of the lips. Apply the cream with your fingers to clean, dry skin. Be sure to wash your hands before and after applying Zovirax cream, and avoid bathing or
swimming afterward to prevent it from washing off. Do not cover the cold sore with a bandage or make-up unless your doctor approves.
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