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Special Wanring
In clinical development programs, sertraline has been evaluated in 1902 subjects with depression. The most commonly observed adverse events associated with the use of sertraline were: gastrointestinal
complaints, including nausea, diarrhea/loose stools and dyspepsia; male sexual dysfunction (primarily ejaculatory delay); insomnia and somnolence; tremor; increased sweating and dry mouth; and dizzin
ess. In the fixed dose placebo controlled study, the overall incidence of side effects was dose related with a majority occurring in the patients treated with 200 mg dose.
The discontinuatio
n rate due to adverse events was 15% in 2710 subjects who received sertraline in premarketing multiple dose clinical trials.
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Why is this drug prescribed?
Zoloft is prescribed for major depressive disorder¡Xa persistently low mood that interferes with everyday living. Symptoms may include loss of interest in your usual activities, disturbed sleep, chang
in appetite, constant fidgeting or lethargic movement, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide.
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Management of Overdoses:
Establish and maintain an airway, insure adequate oxygenation and ventilation. Activated charcoal, which may be used with sorbitol, may be as or more effective than emesis or lavage, and should be con
sidered in treating overdose.
Cardiac and vital signs monitoring are recommended along with general symptomatic and supportive measures.
There are no specific antidotes for sertral
ine.
Due to the large volume of distribution of sertraline, forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit.
In managing overdose,
the possibility of multiple drug involvement must be considered.
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Other medical problems
Pregnancy¡XOne study looked at the babies of 147 women who took Zoloft either at the beginning of pregnancy or through the entire pregnancy. This study found no harmful effects of Zoloft on the babies
However, more study is needed to be sure that Zoloft is safe to use during pregnancy. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
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Proper Use of This Medicine
Zoloft comes as a tablet and concentrate to take by mouth. It is usually taken once daily and may be taken with or without food. Follow the directions on your prescription label carefully, and ask you
r doctor or pharmacist to explain any part you do not understand. Take Zoloft exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continu
e to take Zoloft even if you feel well. Do not stop taking Zoloft without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease y
our dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.
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