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Significant Interactions:
Tricyclic antidepressants (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil
], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil])¡XHigher blood levels of these medicines may occur, which increases the chance of having serious side e
fects. Your doctor may want to see you more often and may need to change the doses of your medicines. Also, taking amitriptyline, clomipramine, or imipramine with fluoxetine may increase the chance of
developing the serotonin syndrome
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Side Effects of This Medicine
In children and adolescents, less common side effects may also include:
- Agitation, excessive menstrual bleeding, frequent urination, hyperactivity, mania or hypomania (inappropriate feelings of
elation and/or rapid thoughts), nosebleeds, personality changes, and thirst
A wide variety of other very rare reactions have been reported during Prozac therapy. If you develop any new or un
explained symptoms, tell your doctor without delay.
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What Is It
Prozac is used to treat mental depression. It is also used to treat obsessive-compulsive disorder, bulimia nervosa, and premenstrual dysphoric disorder.
Prozac also may be used for other cond
itions as determined by your doctor.
Prozac belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). These medicines are thought to work by increasing the act
ivity of a chemical called serotonin in the brain.
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Overdosage
Any medication taken in excess can have serious consequences. An overdose of Prozac can be fatal. In addition, combining Prozac with certain other drugs can cause symptoms of overdose. If you suspect
an overdose, seek medical attention immediately.
Common symptoms of Prozac overdose include:
Nausea, rapid heartbeat, seizures, sleepiness, vomiting
Other symptoms of Prozac ov
erdose include:
Coma, delirium, fainting, high fever, irregular heartbeat, low blood pressure, mania, rigid muscles, sweating, stupor
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Possible food and drug interactions when taking this medication
P450 isozyme (IID6): - Like other selective serotonin reuptake inhibitors, fluoxetine inhibits the specific hepatic cytochrome P450 isozyme (IID6) which is responsible for the metabolism of debrisoqui
ne and sparteine. Although the clinical significance of this effect has not been established, inhibition of IID6 may lead to elevated plasma levels of co-administered drugs which are metabolized by th
is isozyme. Drugs metabolized by cytochrome P450IID6 include the tricyclic antidepressants (e.g., nortriptyline, amitriptyline, imipramine, and desipramine), phenothiazine neuroleptics (e.g., perphena
zine and thioridazine), and Type 1C antiarrhythmics (e.g., propafenone and flecainide).
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Adverse Effects
Urogenital:
Frequent: Painful menstruation, sexual dysfunction, urinary tract infection, frequent micturition.
Infrequent: Abnormal ejaculation, impotence, menopause, amenorrhea, menorrh
agia, ovarian disorder, vaginitis, leukorrhea, fibrocystic breast, breast pain, cystitis, dysuria, urinary urgency, urinary incontinence.
Rare: Breast enlargement, galactorrhea, abortion, dy
spareunia, uterine spasm, vaginal hemorrhage, metrorrhagia, hematuria, albuminuria, polyuria, pyuria, epididymitis, orchitis, pyelonephritis, salpingitis, urethritis, kidney calculus, urethral pain, u
rolithiasis.
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