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Drug Interactions
Include on your medical history/personal profile all of the other medicines you are taking or plan to take while you are on CELEBREX, even other medicines that you can get without a prescription. CELE
BREX has significant drug interactions with :
- Methotrexate (a medicine used to suppress the immune system).
- Warfarin (a blood thinner).
- Rifampin (an antibiotic).
<
br> - ACE inhibitors (medicines used for high blood pressure and heart failure).
- Lithium (a medicine used to treat a certain type of depression).
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How should you take this medication?
You should continue to take CELEBREX as prescribed even when you are feeling better. CELEBREX can be taken with or without food. CELEBREX capsules come in 2 strengths: 100 mg and 200 mg.
In O
steoarthritis, the recommended dose for CELEBREX is 200 mg a day. CELEBREX delivers 24-hour relief from a once-daily dose of 200 mg. Or if preferred, a dose of 100 mg twice a day is available.
In Rheumatoid Arthritis, the recommended dose for CELEBREX is 100 mg to 200 mg, twice a day. CELEBREX provides relief through the day and through the night.
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Overdosage
Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.
Symptoms of Celebrex overdose may include:
Breathing diffic
ulties, coma, drowsiness, gastrointestinal bleeding, high blood pressure, kidney failure, nausea, sluggishness, stomach pain, vomiting
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What side effects may occur?
Although side effects from celecoxib are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:
- water retention
- upset stomach
- sto
mach pain or cramps
- diarrhea
- gas
- headache
If you experience any of the following symptoms, call your doctor immediately:
- bloody vomit
- bloody diarrhea
or black, tarry stools
- ringing in the ears
- blurred vision
- swelling of the hands, feet, ankles, or lower legs
- skin rash
- itching
- yellowing of the skin or eyes <
br> - unexplained weight gain
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Other medical problems
Taking two or more of the nonsteroidal anti-inflammatory drugs together on a regular basis may increase the chance of unwanted effects. Also, taking acetaminophen, aspirin or other salicylates, or ket
orolac (e.g., Toradol) regularly while you are taking a nonsteroidal anti-inflammatory drug may increase the chance of unwanted effects. The risk will depend on how much of each medicine you take ever
y day, and on how long you take the medicines together.However, do not take acetaminophen or aspirin or other salicylates together with this medicine for more than a few days, and do not take any keto
rolac (e.g., Toradol) while you are taking this medicine, unless your doctor has directed you to do so and is following your progress.
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What Is It
Celebrex is prescribed for acute pain, menstrual cramps, and the pain and inflammation of osteoarthritis and rheumatoid arthritis. It is the first of a new class of nonsteroidal anti-inflammatory drug
s (NSAIDs) called "COX-2 inhibitors." Like older NSAIDs such as Motrin and Naprosyn, Celebrex is believed to fight pain and inflammation by inhibiting the effect of a natural enzyme called COX-2. Unli
ke the older medications, however, it does not interfere with a similar substance, called COX-1, which exerts a protective effect on the lining of the stomach. Celebrex is therefore less likely to cau
se the bleeding and ulcers that sometimes accompany sustained use of the older NSAIDs.
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