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Symptoms of overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include sluggishness, change in amount of urine, loss of consciousness, or se
izures.
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Side Effects of This Medicine
Parenteral:
1. Renal toxicity; precipitation of acyclovir crystals can occur in renal tubules if the maximum solubility of free acyclovir (2.5mg/ml at 37?C in water) is exceeded or if the drug is
given by bolus injection. Serum creatinine and BUN rise and creatinine clearance decreases.
2. Encephalopathic changes: Approximately 1% of patients receiving IV acyclovir manifested encephalopath
ic changes characterized by lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures or coma.
3. Other: transient elevation of serum creatinine; rash or hives; diaphoresis; h
ematuria; hypotension; headache and nausea; thrombocytosis.
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Missing Dose
Iit is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of either the ointment or oral medication to make up for a missed one.
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Other medical problems
Pregnancy¡XTopical acyclovir has not been studied in pregnant women. However, this medicine has not been shown to cause birth defects or other problems in animal studies using mice, rats, or rabbits,
xcept when given in very high doses in a study using rats.
Breast-feeding¡XIt is not known whether topical acyclovir passes into the breast milk. However, acyclovir ointment has not been repo
ted to cause problems in nursing babies, even though small amounts of topical acyclovir are absorbed through the mother's skin and mucous membranes. Although most medicines pass into breast milk in sm
all amounts, many of them may be used safely while breast-feeding.
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What is this medicine
Patient information about the treatment of herpes, chickenpox, or shingles is available with this medicine. Read it carefully before using this medicine.
Acyclovir is best used as soon as pos
sible after the symptoms of herpes infection or shingles (for example, pain, burning, blisters) begin to appear.
If you are taking acyclovir for the treatment of chickenpox , it is best to st
art taking acyclovir as soon as possible after the first sign of the chickenpox rash, usually within one day.
Acyclovir capsules, tablets, and oral suspension may be taken with meals or on an
empty stomach.
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Possible food and drug interactions when taking this medication
Inform your doctor if you are taking any of the following:
- Lithium (e.g., Lithane) or
- Methotrexate or
- Other medicine for infection or
- Penicillamine (e.g., Cuprimine)
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